Compound Detail
CHEMBL492445
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL492445 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CENDKGWAICPCEX-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
280.3
MW (Da)
2.50
ALogP
4
HBA
1
HBD
42.9
PSA (Ų)
0.92
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor CHEMBL1867 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Alpha-2C adrenergic receptor CHEMBL1916 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Ki | = | 398.11 | nM | 6.4 | Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A recept... | 18578476 |
| Alpha-2B adrenergic receptor | Ki | = | 1000.0 | nM | 6.0 | Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B recept... | 18578476 |
| Alpha-2C adrenergic receptor | Ki | = | 1258.93 | nM | 5.9 | Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C recep... | 18578476 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18578476 | 10.1021/jm800250z | Alpha-2A adrenergic receptor | 2 |
| 18578476 | 10.1021/jm800250z | Alpha-2B adrenergic receptor | 2 |
| 18578476 | 10.1021/jm800250z | Alpha-2C adrenergic receptor | 2 |
Data from ChEMBL 36 via Core Engine