Assay Detail
Functional
CHEMBL1016581
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Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.56 | 8.00 |
| Activity | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495096 | — | — | 1 | 8.00 |
| CHEMBL451229 | — | — | 1 | 7.68 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 7.30 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 7.24 |
| CHEMBL493675 | — | — | 1 | 6.90 |
| CHEMBL442815 | — | — | 1 | 6.30 |
| CHEMBL523048 | — | — | 1 | 6.11 |
| CHEMBL493272 | — | — | 1 | 6.10 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.10 |
| CHEMBL492639 | — | — | 1 | 6.00 |
| CHEMBL522151 | — | — | 1 | 5.50 |
| CHEMBL495097 | — | — | 1 | 5.45 |
| CHEMBL493674 | — | — | 1 | - |
| CHEMBL492648 | — | — | 1 | - |
| CHEMBL492647 | — | — | 1 | - |
| CHEMBL492445 | — | — | 1 | - |
| CHEMBL492444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495096 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL451229 | — | EC50 | = | 20.89 | nM | 7.68 |
| CHEMBL495095 | ALLYPHENYLINE | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL128168 | BIPHENYLINE | EC50 | = | 57.54 | nM | 7.24 |
| CHEMBL493675 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL442815 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL523048 | — | EC50 | = | 776.25 | nM | 6.11 |
| CHEMBL493272 | — | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL492639 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL522151 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL495097 | — | EC50 | = | 3548.13 | nM | 5.45 |
| CHEMBL493674 | — | Activity | - | — | - | |
| CHEMBL492648 | — | Activity | - | — | - | |
| CHEMBL492647 | — | Activity | - | — | - | |
| CHEMBL492445 | — | Activity | - | — | - | |
| CHEMBL492444 | — | Activity | - | — | - |