Assay Detail
Binding
CHEMBL1019481
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Displacement of [3H]serotonin from human recombinant SERT expressed in HEK293 cells by scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.59 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450907 | — | — | 1 | 8.64 |
| CHEMBL464422 | — | — | 1 | 8.60 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 8.14 |
| CHEMBL473966 | — | — | 1 | 7.74 |
| CHEMBL505431 | — | — | 1 | 6.90 |
| CHEMBL451500 | — | — | 1 | 6.71 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.38 |
| CHEMBL313041 | — | — | 1 | - |
| CHEMBL463431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450907 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL464422 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL473966 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL505431 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL451500 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL370805 | COCAINE | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL313041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL463431 | — | IC50 | > | 100000.0 | nM | - |