Assay Detail
Functional
CHEMBL1020286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isoneocryptolepine, a synthetic indoloquinoline alkaloid, as an antiplasmodial lead compound.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.41 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.66 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.90 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.70 |
| CHEMBL518720 | BISCRYPTOLEPINE | — | 1 | 5.46 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 4.68 |
| CHEMBL463942 | CRYPTOQUINDOLINE | — | 1 | 4.07 |
| CHEMBL463913 | — | — | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL518720 | BISCRYPTOLEPINE | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL463942 | CRYPTOQUINDOLINE | IC50 | = | 84400.0 | nM | 4.07 |
| CHEMBL463913 | — | IC50 | = | 236100.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 1.5 | ug.mL-1 | - |