Assay Detail
Binding
CHEMBL1020360
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Inhibition of Hsp90
13
Total Activities
12
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of heat shock protein 90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.70 | 7.70 |
| EC50 | 4 | 6.54 | 7.80 |
| ED50 | 2 | 7.08 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.80 |
| CHEMBL414883 | RADICICOL | — | 2 | 7.70 |
| CHEMBL365159 | — | — | 1 | 7.52 |
| CHEMBL526127 | POCHONIN D | — | 1 | 7.10 |
| CHEMBL491499 | ZEARALANONE | — | 1 | 7.05 |
| CHEMBL512064 | POCHONIN A | — | 1 | 7.05 |
| CHEMBL468439 | CYCLOPROPARADICICOL | — | 1 | 6.80 |
| CHEMBL200469 | — | — | 1 | 6.59 |
| CHEMBL200255 | — | — | 1 | 6.34 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.00 |
| CHEMBL456678 | — | — | 1 | 5.05 |
| CHEMBL113690 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL414883 | RADICICOL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL365159 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL414883 | RADICICOL | ED50 | = | 45.0 | nM | 7.35 |
| CHEMBL526127 | POCHONIN D | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL491499 | ZEARALANONE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL512064 | POCHONIN A | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL468439 | CYCLOPROPARADICICOL | ED50 | = | 160.0 | nM | 6.80 |
| CHEMBL200469 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL200255 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL109480 | TANESPIMYCIN | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL456678 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL113690 | — | EC50 | = | 15000.0 | nM | 4.82 |