Assay Detail
Binding
CHEMBL1020372
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Binding affinity to Hsp90 by fluorescence polarization assay
9
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and development of heat shock protein 90 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.98 | 7.70 |
| EC50 | 1 | 7.66 | 7.66 |
| Ki | 1 | 5.40 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 7.70 |
| CHEMBL200001 | — | — | 1 | 7.66 |
| CHEMBL365617 | — | — | 1 | 7.60 |
| CHEMBL252124 | — | — | 1 | 7.55 |
| CHEMBL404630 | — | — | 1 | 7.52 |
| CHEMBL251974 | — | — | 1 | 6.22 |
| CHEMBL371915 | — | — | 1 | 6.16 |
| CHEMBL208239 | — | — | 1 | 6.13 |
| CHEMBL514440 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL200001 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL365617 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL252124 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL404630 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL251974 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL371915 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL208239 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL514440 | — | Ki | = | 4000.0 | nM | 5.40 |