Assay Detail
Binding
CHEMBL1031546
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Displacement of [125I]RTI55 from human SERT expressed in HEK cells
36
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 6.96 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460407 | — | — | 1 | 9.10 |
| CHEMBL450907 | — | — | 2 | 8.96 |
| CHEMBL460204 | — | — | 1 | 8.70 |
| CHEMBL462311 | — | — | 1 | 8.68 |
| CHEMBL459367 | — | — | 1 | 8.55 |
| CHEMBL511500 | — | — | 1 | 8.49 |
| CHEMBL455221 | — | — | 1 | 8.40 |
| CHEMBL511163 | — | — | 1 | 7.75 |
| CHEMBL460406 | — | — | 1 | 7.71 |
| CHEMBL456222 | — | — | 1 | 7.70 |
| CHEMBL450769 | — | — | 1 | 7.68 |
| CHEMBL456223 | — | — | 1 | 7.66 |
| CHEMBL458639 | — | — | 1 | 7.37 |
| CHEMBL504028 | — | — | 1 | 7.35 |
| CHEMBL456639 | — | — | 1 | 7.17 |
| CHEMBL459391 | — | — | 1 | 7.07 |
| CHEMBL459390 | — | — | 1 | 7.04 |
| CHEMBL450987 | — | — | 1 | 6.82 |
| CHEMBL456638 | — | — | 1 | 6.76 |
| CHEMBL456221 | — | — | 1 | 6.72 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.56 |
| CHEMBL457968 | — | — | 1 | 6.16 |
| CHEMBL447825 | — | — | 1 | 5.96 |
| CHEMBL461268 | — | — | 1 | 5.95 |
| CHEMBL512736 | — | — | 1 | 5.74 |
| CHEMBL452928 | — | — | 1 | 5.67 |
| CHEMBL448912 | — | — | 1 | 5.42 |
| CHEMBL508678 | — | — | 1 | 5.34 |
| CHEMBL456017 | — | — | 1 | 5.32 |
| CHEMBL442843 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460407 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL450907 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL460204 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL462311 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL459367 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL511500 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL455221 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL450907 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL511163 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL460406 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL456222 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL450769 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL456223 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL458639 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL504028 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL456639 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL459391 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL459390 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL450987 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL456638 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL456221 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL370805 | COCAINE | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL457968 | — | Ki | = | 688.0 | nM | 6.16 |
| CHEMBL447825 | — | Ki | = | 1105.0 | nM | 5.96 |
| CHEMBL461268 | — | Ki | = | 1114.0 | nM | 5.95 |
| CHEMBL512736 | — | Ki | = | 1808.0 | nM | 5.74 |
| CHEMBL452928 | — | Ki | = | 2126.0 | nM | 5.67 |
| CHEMBL448912 | — | Ki | = | 3822.0 | nM | 5.42 |
| CHEMBL508678 | — | Ki | = | 4546.0 | nM | 5.34 |
| CHEMBL456017 | — | Ki | = | 4772.0 | nM | 5.32 |
| CHEMBL442843 | — | Ki | = | 6307.0 | nM | 5.20 |
| CHEMBL451652 | — | Ki | = | 6877.0 | nM | 5.16 |
| CHEMBL457967 | — | Ki | = | 6885.0 | nM | 5.16 |
| CHEMBL457966 | — | Ki | = | 7483.0 | nM | 5.13 |
| CHEMBL447750 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL451837 | — | Ki | > | 10000.0 | nM | - |