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Assay Detail

CHEMBL1066766

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Binding
Inhibition of rabbit muscle glycogen phosphorylase b
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen phosphorylase, muscle form (CHEMBL4696)
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors.
Benltifa M, Hayes JM, Vidal S, Gueyrard D, Goekjian PG, Praly JP, Kizilis G, Tiraidis C, Alexacou KM, Chrysina ED, Zographos SE, Leonidas DD, Archontis G, Oikonomakos NG.
Bioorg Med Chem (2009) 17 : 7368 -7380
PubMed 19781947 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 4.92 6.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL594021 1 6.20
CHEMBL510975 1 5.51
CHEMBL489798 1 5.29
CHEMBL593092 1 5.18
CHEMBL594971 1 5.10
CHEMBL594972 1 4.71
CHEMBL595439 1 4.54
CHEMBL611940 1 4.41
CHEMBL593790 1 4.22
CHEMBL608390 1 4.03
CHEMBL423707 1 -
CHEMBL608719 1 -
CHEMBL609856 1 -
CHEMBL593335 1 -
CHEMBL594722 1 -
CHEMBL593791 1 -
CHEMBL611939 1 -
CHEMBL595664 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL594021 Ki = 630.0 nM 6.20
CHEMBL510975 Ki = 3100.0 nM 5.51
CHEMBL489798 Ki = 5100.0 nM 5.29
CHEMBL593092 Ki = 6600.0 nM 5.18
CHEMBL594971 Ki = 7900.0 nM 5.10
CHEMBL594972 Ki = 19600.0 nM 4.71
CHEMBL595439 Ki = 28600.0 nM 4.54
CHEMBL611940 Ki = 39000.0 nM 4.41
CHEMBL593790 Ki = 59700.0 nM 4.22
CHEMBL608390 Ki = 92500.0 nM 4.03
CHEMBL423707 Ki = 1700000.0 nM -
CHEMBL608719 Ki = 8200000.0 nM -
CHEMBL609856 Ki = 220000000.0 nM -
CHEMBL593335 Ki = 550000.0 nM -
CHEMBL594722 Ki = 146000.0 nM -
CHEMBL593791 Ki = 1200000.0 nM -
CHEMBL611939 Ki > 10000000.0 nM -
CHEMBL595664 Ki > 11500000.0 nM -