Assay Detail
Functional
CHEMBL1066769
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Antitrypanosomal activity against Trypanosoma cruzi
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.00 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 6.66 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.90 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.90 |
| CHEMBL594246 | — | — | 1 | 5.82 |
| CHEMBL593930 | — | — | 1 | 5.78 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 5.70 |
| CHEMBL593792 | — | — | 1 | 4.92 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | — | 1 | 4.68 |
| CHEMBL607530 | — | — | 1 | 4.68 |
| CHEMBL594030 | — | — | 1 | 4.39 |
| CHEMBL593688 | — | — | 1 | 4.19 |
| CHEMBL609575 | — | — | 1 | 4.16 |
| CHEMBL593018 | — | — | 1 | 4.12 |
| CHEMBL593073 | — | — | 1 | 4.09 |
| CHEMBL593094 | — | — | 1 | 4.05 |
| CHEMBL595665 | — | — | 1 | - |
| CHEMBL594240 | — | — | 1 | - |
| CHEMBL408157 | — | — | 1 | - |
| CHEMBL367738 | — | — | 1 | - |
| CHEMBL593072 | — | — | 1 | - |
| CHEMBL608989 | — | — | 1 | - |
| CHEMBL593929 | — | — | 1 | - |
| CHEMBL594467 | — | — | 1 | - |
| CHEMBL594400 | — | — | 1 | - |
| CHEMBL455600 | — | — | 1 | - |
| CHEMBL596112 | — | — | 1 | - |
| CHEMBL593231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL502768 | ISOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL594246 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL593930 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL465591 | NEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL593792 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL512770 | ISONEOCRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL607530 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL594030 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL593688 | — | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL609575 | — | IC50 | = | 69600.0 | nM | 4.16 |
| CHEMBL593018 | — | IC50 | = | 76800.0 | nM | 4.12 |
| CHEMBL593073 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL593094 | — | IC50 | = | 89200.0 | nM | 4.05 |
| CHEMBL595665 | — | IC50 | > | 115000.0 | nM | - |
| CHEMBL594240 | — | IC50 | > | 160000.0 | nM | - |
| CHEMBL408157 | — | IC50 | > | 160000.0 | nM | - |
| CHEMBL367738 | — | IC50 | > | 160000.0 | nM | - |
| CHEMBL593072 | — | IC50 | > | 225000.0 | nM | - |
| CHEMBL608989 | — | IC50 | > | 225000.0 | nM | - |
| CHEMBL593929 | — | IC50 | > | 225000.0 | nM | - |
| CHEMBL594467 | — | IC50 | > | 225000.0 | nM | - |
| CHEMBL594400 | — | IC50 | > | 225000.0 | nM | - |
| CHEMBL455600 | — | IC50 | > | 95000.0 | nM | - |
| CHEMBL596112 | — | IC50 | > | 95000.0 | nM | - |
| CHEMBL593231 | — | IC50 | > | 95000.0 | nM | - |