Assay Detail
Binding
CHEMBL1067396
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Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cells by microplate scintillation counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 4.63 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74300 | — | — | 1 | 5.62 |
| CHEMBL390842 | — | — | 1 | 5.12 |
| CHEMBL593620 | — | — | 1 | 4.98 |
| CHEMBL595265 | — | — | 1 | 4.96 |
| CHEMBL593685 | — | — | 1 | 4.79 |
| CHEMBL594801 | — | — | 1 | 4.67 |
| CHEMBL594803 | — | — | 1 | 4.49 |
| CHEMBL404557 | — | — | 1 | 4.45 |
| CHEMBL593861 | — | — | 1 | 4.39 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 4.36 |
| CHEMBL593443 | — | — | 1 | 4.35 |
| CHEMBL595022 | — | — | 1 | 4.33 |
| CHEMBL594376 | — | — | 1 | 4.18 |
| CHEMBL594802 | — | — | 1 | 4.11 |
| CHEMBL593871 | — | — | 1 | - |
| CHEMBL608985 | — | — | 1 | - |
| CHEMBL593864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74300 | — | Ki | = | 2398.83 | nM | 5.62 |
| CHEMBL390842 | — | Ki | = | 7585.78 | nM | 5.12 |
| CHEMBL593620 | — | Ki | = | 10471.29 | nM | 4.98 |
| CHEMBL595265 | — | Ki | = | 10964.78 | nM | 4.96 |
| CHEMBL593685 | — | Ki | = | 16218.1 | nM | 4.79 |
| CHEMBL594801 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL594803 | — | Ki | = | 32359.37 | nM | 4.49 |
| CHEMBL404557 | — | Ki | = | 35481.34 | nM | 4.45 |
| CHEMBL593861 | — | Ki | = | 40738.03 | nM | 4.39 |
| CHEMBL14 | CARBACHOL | Ki | = | 43651.58 | nM | 4.36 |
| CHEMBL593443 | — | Ki | = | 44668.36 | nM | 4.35 |
| CHEMBL595022 | — | Ki | = | 46773.51 | nM | 4.33 |
| CHEMBL594376 | — | Ki | = | 66069.34 | nM | 4.18 |
| CHEMBL594802 | — | Ki | = | 77624.71 | nM | 4.11 |
| CHEMBL593871 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL608985 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL593864 | — | Ki | > | 100000.0 | nM | - |