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Compound Detail

CHEMBL593861

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CC1(C)OC[C@@H](C[N+](C)(C)C)OC1(C)C.[I-]

Basic Information

ChEMBL ID CHEMBL593861
Phase Preclinical
Structure Type MOL
InChI Key HHQWGXVMIJSVBU-HNCPQSOCSA-M
Parent Compound CHEMBL1198047
Active Moiety CHEMBL1198047
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

216.3
MW (Da)
1.67
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H26INO2
MW 343.25
Aromatic Rings 0
Heavy Atoms 15
NP-Likeness 0.88

Activity Summary

Ki 4 meas. best 4.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 4.39 4.39 40738.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 4.33 4.33 46773.5 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 4.27 4.27 53703.2 1
Muscarinic acetylcholine receptor M5
CHEMBL2035
Ki 4.18 4.18 66069.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19896386 10.1016/j.bmc.2009.10.027 Unchecked 5
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M3 3
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M1 1
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M2 1
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M4 1
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M5 1

Data from ChEMBL 36 via Core Engine