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Compound Detail

CHEMBL594376

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C[C@@H]1CO[C@H](C[N+](C)(C)C)CO1.[I-]

Basic Information

ChEMBL ID CHEMBL594376
Phase Preclinical
Structure Type MOL
InChI Key MMFSFQDCALVVNK-VTLYIQCISA-M
Parent Compound CHEMBL1198062
Active Moiety CHEMBL1198062
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

174.3
MW (Da)
0.50
ALogP
2
HBA
0
HBD
18.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H20INO2
MW 301.17
Aromatic Rings 0
Heavy Atoms 12
NP-Likeness 0.64

Activity Summary

Ki 4 meas. best 4.95

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 4.95 4.95 11220.2 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 4.18 4.18 66069.3 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 4.03 4.03 93325.4 1
Muscarinic acetylcholine receptor M5
CHEMBL2035
Ki 4.03 4.03 93325.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19896386 10.1016/j.bmc.2009.10.027 Unchecked 6
24980056 10.1016/j.bmcl.2014.06.020 Unchecked 6
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M3 3
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M1 1
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M2 1
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M5 1
19896386 10.1016/j.bmc.2009.10.027 Muscarinic acetylcholine receptor M4 1

Data from ChEMBL 36 via Core Engine