Assay Detail
Functional
CHEMBL1070570
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Induction of ABCA1 mRNA upregulation in human THP1 cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 6.60 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595012 | — | — | 1 | 8.00 |
| CHEMBL595689 | — | — | 1 | 8.00 |
| CHEMBL605730 | — | — | 1 | 7.85 |
| CHEMBL62136 | T091317 | — | 1 | 7.46 |
| CHEMBL595936 | — | — | 1 | 7.11 |
| CHEMBL595454 | — | — | 1 | 6.96 |
| CHEMBL603636 | — | — | 1 | 6.86 |
| CHEMBL606143 | — | — | 1 | 6.81 |
| CHEMBL594367 | — | — | 1 | 6.81 |
| CHEMBL594063 | — | — | 1 | 6.81 |
| CHEMBL595455 | — | — | 1 | 6.67 |
| CHEMBL595248 | — | — | 1 | 6.62 |
| CHEMBL595249 | — | — | 1 | 6.61 |
| CHEMBL594994 | — | — | 1 | 6.57 |
| CHEMBL594050 | — | — | 1 | 6.55 |
| CHEMBL595224 | — | — | 1 | 6.48 |
| CHEMBL595483 | — | — | 1 | 6.45 |
| CHEMBL594288 | — | — | 1 | 6.37 |
| CHEMBL594757 | — | — | 1 | 6.37 |
| CHEMBL595011 | — | — | 1 | 6.36 |
| CHEMBL605723 | — | — | 1 | 6.21 |
| CHEMBL593814 | — | — | 1 | 6.12 |
| CHEMBL595222 | — | — | 1 | 6.08 |
| CHEMBL594983 | — | — | 1 | 5.97 |
| CHEMBL594984 | — | — | 1 | 5.90 |
| CHEMBL596593 | — | — | 1 | 5.89 |
| CHEMBL604907 | — | — | 1 | 5.88 |
| CHEMBL596591 | — | — | 1 | 5.88 |
| CHEMBL596592 | — | — | 1 | 5.86 |
| CHEMBL594062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595012 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL595689 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL605730 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL62136 | T091317 | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL595936 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL595454 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL603636 | — | EC50 | = | 137.0 | nM | 6.86 |
| CHEMBL606143 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL594367 | — | EC50 | = | 155.0 | nM | 6.81 |
| CHEMBL594063 | — | EC50 | = | 156.0 | nM | 6.81 |
| CHEMBL595455 | — | EC50 | = | 215.0 | nM | 6.67 |
| CHEMBL595248 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL595249 | — | EC50 | = | 245.0 | nM | 6.61 |
| CHEMBL594994 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL594050 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL595224 | — | EC50 | = | 333.0 | nM | 6.48 |
| CHEMBL595483 | — | EC50 | = | 357.0 | nM | 6.45 |
| CHEMBL594288 | — | EC50 | = | 425.0 | nM | 6.37 |
| CHEMBL594757 | — | EC50 | = | 425.0 | nM | 6.37 |
| CHEMBL595011 | — | EC50 | = | 439.0 | nM | 6.36 |
| CHEMBL605723 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL593814 | — | EC50 | = | 753.0 | nM | 6.12 |
| CHEMBL595222 | — | EC50 | = | 841.0 | nM | 6.08 |
| CHEMBL594983 | — | EC50 | = | 1067.0 | nM | 5.97 |
| CHEMBL594984 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL596593 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL604907 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL596591 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL596592 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL594062 | — | EC50 | - | — | - | |
| CHEMBL595482 | — | EC50 | - | — | - |