Assay Detail
Functional
CHEMBL1099528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 amastigotes after 48 hrs by alamar blue assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania mexicana |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 4.62 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103410 | — | — | 1 | 5.50 |
| CHEMBL1088447 | — | — | 1 | 5.34 |
| CHEMBL482607 | — | — | 1 | 5.32 |
| CHEMBL1082222 | — | — | 1 | 5.15 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | — | 1 | 5.00 |
| CHEMBL319488 | DIDEMETHYLCURCUMIN | — | 1 | 4.92 |
| CHEMBL1087679 | — | — | 1 | 4.92 |
| CHEMBL1085419 | — | — | 1 | 4.85 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.80 |
| CHEMBL1087259 | — | — | 1 | 4.80 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.80 |
| CHEMBL1086746 | — | — | 1 | 4.77 |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | — | 1 | 4.77 |
| CHEMBL330645 | PLATYPHYLLENONE | — | 1 | 4.68 |
| CHEMBL1083516 | — | — | 1 | 4.68 |
| CHEMBL1087690 | — | — | 1 | 4.68 |
| CHEMBL1088446 | — | — | 1 | 4.66 |
| CHEMBL1087807 | — | — | 1 | 4.57 |
| CHEMBL1087808 | — | — | 1 | 4.57 |
| CHEMBL1088445 | — | — | 1 | 4.55 |
| CHEMBL1088638 | — | — | 1 | 4.52 |
| CHEMBL1088197 | — | — | 1 | 4.50 |
| CHEMBL1085418 | — | — | 1 | 4.50 |
| CHEMBL261297 | — | — | 1 | 4.47 |
| CHEMBL1087678 | — | — | 1 | 4.47 |
| CHEMBL1086759 | — | — | 1 | 4.46 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | — | 1 | 4.43 |
| CHEMBL1088639 | — | — | 1 | 4.43 |
| CHEMBL1088195 | — | — | 1 | 4.42 |
| CHEMBL318743 | TETRAHYDROCURCUMIN | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103410 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1088447 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL482607 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1082222 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL319488 | DIDEMETHYLCURCUMIN | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1087679 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1085419 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL140 | CURCUMIN | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1087259 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1086746 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1083516 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL330645 | PLATYPHYLLENONE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1087690 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1088446 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1087807 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1087808 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1088445 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1088638 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1088197 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1085418 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL261297 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1087678 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1086759 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1088639 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1088195 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL318743 | TETRAHYDROCURCUMIN | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1086394 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1086758 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1087260 | DIDEMETHYLTETRAHYDROCURCUMIN | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1088196 | — | EC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1088457 | — | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL443146 | LETESTUIANIN C | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1082223 | — | EC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL1087507 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1088293 | — | EC50 | - | — | - | |
| CHEMBL479650 | HEXAHYDROCURCUMIN | EC50 | > | 100000.0 | nM | - |
| CHEMBL1087517 | OCTAHYDROCURCUMIN | EC50 | > | 100000.0 | nM | - |
| CHEMBL1087639 | TETRAHYDRODEMETHOXYCURCUMIN | EC50 | > | 50000.0 | nM | - |
| CHEMBL1087381 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL150000 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1087506 | — | EC50 | - | — | - | |
| CHEMBL1077099 | — | EC50 | - | — | - | |
| CHEMBL1087689 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1086760 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1088425 | — | EC50 | > | 100000.0 | nM | - |