Compound Detail
CHEMBL1086758
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1086758 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UIKHEKQJQZEPJM-GXDHUFHOSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
496.7
MW (Da)
7.53
ALogP
5
HBA
0
HBD
54.0
PSA (Ų)
0.15
QED
1
Ro5 Violations
19
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 6 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | EC50 | 5.96 | 5.8767 | 1100.0 | 3 |
| Leishmania major CHEMBL612879 | EC50 | 5.18 | 5.18 | 6600.0 | 1 |
| HEK293 CHEMBL614818 | EC50 | 4.37 | 4.37 | 43000.0 | 1 |
| Leishmania mexicana CHEMBL612880 | EC50 | 4.28 | 4.28 | 53000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | EC50 | = | 1100.0 | nM | 5.96 | Antitrypanosomal activity against Trypanosoma brucei brucei 427 after 48 hrs by ... | 20004045 |
| Trypanosoma brucei brucei | EC50 | = | 1200.0 | nM | 5.92 | Antitrypanosomal activity against diminazene-resistant Trypanosoma brucei brucei... | 20004045 |
| Trypanosoma brucei brucei | EC50 | = | 1800.0 | nM | 5.75 | Antitrypanosomal activity against multidrug-resistant Trypanosoma brucei brucei ... | 20004045 |
| Leishmania major | EC50 | = | 6600.0 | nM | 5.18 | Antileishmanial activity against Leishmania major Friedlin promastigotes after 4... | 20004045 |
| HEK293 | EC50 | = | 43000.0 | nM | 4.37 | Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay | 20004045 |
| Leishmania mexicana | EC50 | = | 53000.0 | nM | 4.28 | Antileishmanial activity against Leishmania mexicana MNYC/BZ/62/M379 amastigotes... | 20004045 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20004045 | 10.1016/j.ejmech.2009.11.035 | Trypanosoma brucei brucei | 3 |
| 20004045 | 10.1016/j.ejmech.2009.11.035 | Leishmania major | 1 |
| 20004045 | 10.1016/j.ejmech.2009.11.035 | Leishmania mexicana | 1 |
| 20004045 | 10.1016/j.ejmech.2009.11.035 | HEK293 | 1 |
Data from ChEMBL 36 via Core Engine