Assay Detail
Functional
CHEMBL1099525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against diminazene-resistant Trypanosoma brucei brucei deltaTbat1-KO after 48 hrs by alamar blue assay
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 50 | 5.51 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1086759 | — | — | 1 | 7.38 |
| CHEMBL1086746 | — | — | 1 | 7.09 |
| CHEMBL1088447 | — | — | 1 | 6.66 |
| CHEMBL1087259 | — | — | 1 | 6.28 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | — | 1 | 6.21 |
| CHEMBL1085418 | — | — | 1 | 6.07 |
| CHEMBL103410 | — | — | 1 | 5.96 |
| CHEMBL1086758 | — | — | 1 | 5.92 |
| CHEMBL482607 | — | — | 1 | 5.85 |
| CHEMBL1087260 | DIDEMETHYLTETRAHYDROCURCUMIN | — | 1 | 5.82 |
| CHEMBL1087807 | — | — | 1 | 5.80 |
| CHEMBL1088445 | — | — | 1 | 5.80 |
| CHEMBL1087381 | — | — | 1 | 5.80 |
| CHEMBL1087690 | — | — | 1 | 5.77 |
| CHEMBL1083516 | — | — | 1 | 5.75 |
| CHEMBL1087678 | — | — | 1 | 5.75 |
| CHEMBL1087689 | — | — | 1 | 5.72 |
| CHEMBL330645 | PLATYPHYLLENONE | — | 1 | 5.72 |
| CHEMBL1088196 | — | — | 1 | 5.72 |
| CHEMBL1088195 | — | — | 1 | 5.70 |
| CHEMBL1086394 | — | — | 1 | 5.70 |
| CHEMBL1087679 | — | — | 1 | 5.66 |
| CHEMBL261297 | — | — | 1 | 5.66 |
| CHEMBL1088639 | — | — | 1 | 5.64 |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | 5.62 |
| CHEMBL319488 | DIDEMETHYLCURCUMIN | — | 1 | 5.60 |
| CHEMBL1088638 | — | — | 1 | 5.54 |
| CHEMBL1087808 | — | — | 1 | 5.54 |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | — | 1 | 5.50 |
| CHEMBL1082223 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1086759 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1086746 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1088447 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1087259 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1085418 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL103410 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1086758 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL482607 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1087260 | DIDEMETHYLTETRAHYDROCURCUMIN | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1087807 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1088445 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1087381 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1087690 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1087678 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1083516 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1087689 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL330645 | PLATYPHYLLENONE | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1088196 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1088195 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1086394 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1087679 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL261297 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1088639 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL319488 | DIDEMETHYLCURCUMIN | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1087808 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1088638 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1082223 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1082222 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL443146 | LETESTUIANIN C | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL140 | CURCUMIN | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1088425 | — | EC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL1088197 | — | EC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1088446 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1087507 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1085419 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL150000 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1086760 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1087639 | TETRAHYDRODEMETHOXYCURCUMIN | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL318743 | TETRAHYDROCURCUMIN | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL479650 | HEXAHYDROCURCUMIN | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1088457 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL1087517 | OCTAHYDROCURCUMIN | EC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1088293 | — | EC50 | - | — | - | |
| CHEMBL1087506 | — | EC50 | - | — | - | |
| CHEMBL1077099 | — | EC50 | - | — | - |