Assay Detail
ADMET
CHEMBL1099529
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Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 49 | 4.42 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1088447 | — | — | 1 | 5.09 |
| CHEMBL1088639 | — | — | 1 | 4.70 |
| CHEMBL482607 | — | — | 1 | 4.66 |
| CHEMBL1086746 | — | — | 1 | 4.62 |
| CHEMBL1088638 | — | — | 1 | 4.60 |
| CHEMBL1088445 | — | — | 1 | 4.58 |
| CHEMBL1083516 | — | — | 1 | 4.52 |
| CHEMBL1086759 | — | — | 1 | 4.52 |
| CHEMBL103410 | — | — | 1 | 4.44 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.43 |
| CHEMBL319488 | DIDEMETHYLCURCUMIN | — | 1 | 4.41 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | — | 1 | 4.40 |
| CHEMBL1086758 | — | — | 1 | 4.37 |
| CHEMBL330645 | PLATYPHYLLENONE | — | 1 | 4.35 |
| CHEMBL1085418 | — | — | 1 | 4.34 |
| CHEMBL1086394 | — | — | 1 | 4.31 |
| CHEMBL1088446 | — | — | 1 | 4.12 |
| CHEMBL1088195 | — | — | 1 | 4.10 |
| CHEMBL261297 | — | — | 1 | 4.10 |
| CHEMBL1085419 | — | — | 1 | 4.09 |
| CHEMBL1082223 | — | — | 1 | 4.03 |
| CHEMBL479650 | HEXAHYDROCURCUMIN | — | 1 | - |
| CHEMBL1087517 | OCTAHYDROCURCUMIN | — | 1 | - |
| CHEMBL1088457 | — | — | 1 | - |
| CHEMBL1087639 | TETRAHYDRODEMETHOXYCURCUMIN | — | 1 | - |
| CHEMBL443146 | LETESTUIANIN C | — | 1 | - |
| CHEMBL1087259 | — | — | 1 | - |
| CHEMBL1087260 | DIDEMETHYLTETRAHYDROCURCUMIN | — | 1 | - |
| CHEMBL150000 | — | — | 1 | - |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1088447 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1088639 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL482607 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1086746 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL1088638 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1088445 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1083516 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1086759 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL103410 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL140 | CURCUMIN | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL319488 | DIDEMETHYLCURCUMIN | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1086758 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL330645 | PLATYPHYLLENONE | EC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1085418 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1086394 | — | EC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL1088446 | — | EC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL1088195 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL261297 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1085419 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL1082223 | — | EC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL1088197 | — | EC50 | = | 400000.0 | nM | - |
| CHEMBL1087678 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL1087679 | — | EC50 | = | 270000.0 | nM | - |
| CHEMBL1087689 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL1087690 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL318743 | TETRAHYDROCURCUMIN | EC50 | = | 120000.0 | nM | - |
| CHEMBL1087808 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL1082222 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL1077099 | — | EC50 | - | — | - | |
| CHEMBL1088425 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL1087381 | — | EC50 | = | 370000.0 | nM | - |
| CHEMBL1087506 | — | EC50 | - | — | - | |
| CHEMBL1087507 | — | EC50 | = | 270000.0 | nM | - |
| CHEMBL1088293 | — | EC50 | - | — | - | |
| CHEMBL1088196 | — | EC50 | = | 690000.0 | nM | - |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | EC50 | = | 200000.0 | nM | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | EC50 | = | 200000.0 | nM | - |
| CHEMBL1087807 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL1086760 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL464274 | DEHYDROHIRSUTANONOL | EC50 | = | 220000.0 | nM | - |
| CHEMBL150000 | — | EC50 | = | 370000.0 | nM | - |
| CHEMBL1087260 | DIDEMETHYLTETRAHYDROCURCUMIN | EC50 | = | 150000.0 | nM | - |
| CHEMBL1087259 | — | EC50 | = | 130000.0 | nM | - |
| CHEMBL443146 | LETESTUIANIN C | EC50 | = | 350000.0 | nM | - |
| CHEMBL1087639 | TETRAHYDRODEMETHOXYCURCUMIN | EC50 | - | — | - | |
| CHEMBL1088457 | — | EC50 | = | 130000.0 | nM | - |
| CHEMBL1087517 | OCTAHYDROCURCUMIN | EC50 | - | — | - | |
| CHEMBL479650 | HEXAHYDROCURCUMIN | EC50 | = | 370000.0 | nM | - |