Assay Detail
Binding
CHEMBL1100127
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Displacement of [3H]prazosin from human Alpha-1B adrenergic receptor expressed in CHO cells
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new series of 5-HT1A receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.99 | 7.70 |
| pKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078773 | — | — | 1 | 7.70 |
| CHEMBL1088072 | — | — | 1 | 7.38 |
| CHEMBL1082862 | — | — | 1 | 7.33 |
| CHEMBL1078953 | — | — | 1 | 7.27 |
| CHEMBL1077168 | — | — | 1 | 7.23 |
| CHEMBL1083181 | — | — | 1 | 7.20 |
| CHEMBL1087942 | — | — | 1 | 7.12 |
| CHEMBL1083182 | — | — | 1 | 7.00 |
| CHEMBL1086156 | — | — | 1 | 6.93 |
| CHEMBL1079065 | — | — | 1 | 6.86 |
| CHEMBL1079066 | — | — | 1 | 6.76 |
| CHEMBL1084658 | — | — | 1 | 6.62 |
| CHEMBL1078954 | — | — | 1 | 6.35 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.15 |
| CHEMBL1078751 | — | — | 1 | - |
| CHEMBL1078750 | — | — | 1 | - |
| CHEMBL1078772 | — | — | 1 | - |
| CHEMBL1088071 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078773 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL1088072 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL1082862 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL1078953 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL1077168 | — | Ki | = | 58.88 | nM | 7.23 |
| CHEMBL1083181 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL1087942 | — | Ki | = | 75.86 | nM | 7.12 |
| CHEMBL1083182 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1086156 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL1079065 | — | Ki | = | 138.04 | nM | 6.86 |
| CHEMBL1079066 | — | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL1084658 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL1078954 | — | Ki | = | 446.68 | nM | 6.35 |
| CHEMBL13647 | BMY-7378 | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL1078751 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1078750 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1078772 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1088071 | — | pKi | - | — | - | |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 1000.0 | nM | - |