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Compound Detail

CHEMBL1079065

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COc1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1OC

Basic Information

ChEMBL ID CHEMBL1079065
Phase Preclinical
Structure Type MOL
InChI Key NTHBZKNEJJJYGF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

435.5
MW (Da)
3.99
ALogP
6
HBA
1
HBD
58.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H29NO5
MW 435.52
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.02

Activity Summary

Ki 2 meas. best 7.01

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL214
Ki 7.01 7.01 97.7 1
Alpha-1B adrenergic receptor
CHEMBL232
Ki 6.86 6.86 138.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20185311 10.1016/j.bmcl.2010.01.030 Alpha-1A adrenergic receptor 1
20185311 10.1016/j.bmcl.2010.01.030 Alpha-1B adrenergic receptor 1
20185311 10.1016/j.bmcl.2010.01.030 Alpha-1D adrenergic receptor 1
20185311 10.1016/j.bmcl.2010.01.030 5-hydroxytryptamine receptor 1A 1
20185311 10.1016/j.bmcl.2010.01.030 Vas deferens 1
20185311 10.1016/j.bmcl.2010.01.030 Spleen 1
20185311 10.1016/j.bmcl.2010.01.030 Thoracic aorta 1
20185311 10.1016/j.bmcl.2010.01.030 Unchecked 1

Data from ChEMBL 36 via Core Engine