Assay Detail
Binding
CHEMBL1113943
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Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.03 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.50 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | — | 1 | 6.76 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 6.68 |
| CHEMBL1077900 | — | — | 1 | 6.40 |
| CHEMBL1078038 | — | — | 1 | 6.38 |
| CHEMBL1078440 | — | — | 1 | 6.36 |
| CHEMBL1077857 | — | — | 1 | 6.36 |
| CHEMBL1077873 | — | — | 1 | 6.32 |
| CHEMBL1079254 | — | — | 1 | 6.28 |
| CHEMBL1078835 | — | — | 1 | 6.28 |
| CHEMBL1078920 | — | — | 1 | 6.22 |
| CHEMBL1077898 | — | — | 1 | 6.21 |
| CHEMBL1078352 | — | — | 1 | 6.21 |
| CHEMBL1077874 | — | — | 1 | 6.20 |
| CHEMBL1077961 | — | — | 1 | 6.18 |
| CHEMBL1079057 | — | — | 1 | 6.17 |
| CHEMBL1079255 | — | — | 1 | 6.16 |
| CHEMBL1078183 | — | — | 1 | 6.16 |
| CHEMBL1079149 | — | — | 1 | 6.15 |
| CHEMBL1077872 | — | — | 1 | 6.14 |
| CHEMBL1077897 | — | — | 1 | 6.08 |
| CHEMBL1078510 | — | — | 1 | 6.06 |
| CHEMBL1078818 | — | — | 1 | 6.06 |
| CHEMBL1078039 | — | — | 1 | 6.02 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 6.00 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 5.97 |
| CHEMBL1077883 | — | — | 1 | 5.89 |
| CHEMBL193309 | — | — | 1 | 5.85 |
| CHEMBL1077983 | — | — | 1 | 5.84 |
| CHEMBL1077875 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549 | CITALOPRAM | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL1077900 | — | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL1078038 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL1078440 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL1077857 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL1077873 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL1079254 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL1078835 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL1078920 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL1077898 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL1078352 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL1077874 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL1077961 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL1079057 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL1079255 | — | IC50 | = | 688.0 | nM | 6.16 |
| CHEMBL1078183 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL1079149 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL1077872 | — | IC50 | = | 724.0 | nM | 6.14 |
| CHEMBL1077897 | — | IC50 | = | 823.0 | nM | 6.08 |
| CHEMBL1078818 | — | IC50 | = | 872.0 | nM | 6.06 |
| CHEMBL1078510 | — | IC50 | = | 868.0 | nM | 6.06 |
| CHEMBL1078039 | — | IC50 | = | 963.0 | nM | 6.02 |
| CHEMBL6731 | TENAMFETAMINE | IC50 | = | 996.0 | nM | 6.00 |
| CHEMBL43048 | MIDOMAFETAMINE | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL1077883 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL193309 | — | IC50 | = | 1403.0 | nM | 5.85 |
| CHEMBL1077983 | — | IC50 | = | 1446.0 | nM | 5.84 |
| CHEMBL1077875 | — | IC50 | = | 1575.0 | nM | 5.80 |
| CHEMBL1077884 | — | IC50 | = | 1804.0 | nM | 5.74 |
| CHEMBL1079148 | — | IC50 | = | 1854.0 | nM | 5.73 |
| CHEMBL1078836 | — | IC50 | = | 1875.0 | nM | 5.73 |
| CHEMBL1077899 | — | IC50 | = | 1939.0 | nM | 5.71 |
| CHEMBL1078351 | — | IC50 | = | 2003.0 | nM | 5.70 |
| CHEMBL1077901 | — | IC50 | = | 2821.0 | nM | 5.55 |
| CHEMBL1078834 | — | IC50 | = | 3583.0 | nM | 5.45 |
| CHEMBL1078716 | — | IC50 | = | 14330.0 | nM | 4.84 |
| CHEMBL1078837 | — | IC50 | = | 25060.0 | nM | 4.60 |
| CHEMBL1079058 | — | IC50 | = | 43290.0 | nM | 4.36 |
| CHEMBL1078098 | — | IC50 | > | 25000.0 | nM | - |