Assay Detail
Binding
CHEMBL1116559
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of human SERT-dependent cytotoxicity in SERT expressing human DG75 cells after 48 hrs by neutral red assay
47
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DG75 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 4.64 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078716 | — | — | 2 | 5.53 |
| CHEMBL1078098 | — | — | 1 | 5.32 |
| CHEMBL1079057 | — | — | 2 | 5.31 |
| CHEMBL1078948 | — | — | 1 | 5.11 |
| CHEMBL1079058 | — | — | 2 | 4.76 |
| CHEMBL1077875 | — | — | 1 | 4.73 |
| CHEMBL193309 | — | — | 2 | 4.64 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | — | 1 | 4.49 |
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 4.49 |
| CHEMBL1078834 | — | — | 1 | 4.48 |
| CHEMBL1079255 | — | — | 1 | 4.42 |
| CHEMBL1078440 | — | — | 1 | 4.33 |
| CHEMBL1078818 | — | — | 1 | 4.22 |
| CHEMBL1077883 | — | — | 1 | 4.16 |
| CHEMBL1077983 | — | — | 1 | 4.11 |
| CHEMBL1078920 | — | — | 1 | 4.11 |
| CHEMBL1077897 | — | — | 1 | - |
| CHEMBL1078099 | — | — | 1 | - |
| CHEMBL1078352 | — | — | 1 | - |
| CHEMBL1077898 | — | — | 1 | - |
| CHEMBL1078351 | — | — | 1 | - |
| CHEMBL1077899 | — | — | 1 | - |
| CHEMBL1077900 | — | — | 1 | - |
| CHEMBL1077901 | — | — | 1 | - |
| CHEMBL1078183 | — | — | 1 | - |
| CHEMBL1077884 | — | — | 1 | - |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | - |
| CHEMBL1077874 | — | — | 1 | - |
| CHEMBL1077873 | — | — | 1 | - |
| CHEMBL1077872 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078716 | — | EC50 | = | 2951.21 | nM | 5.53 |
| CHEMBL1078098 | — | EC50 | = | 4786.3 | nM | 5.32 |
| CHEMBL1079057 | — | EC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL1078948 | — | EC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL1079058 | — | EC50 | = | 17378.01 | nM | 4.76 |
| CHEMBL1077875 | — | EC50 | = | 18620.87 | nM | 4.73 |
| CHEMBL193309 | — | EC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL278663 | PARA-METHOXYAMPHETAMINE | EC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL43048 | MIDOMAFETAMINE | EC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL1078834 | — | EC50 | = | 33113.11 | nM | 4.48 |
| CHEMBL1079255 | — | EC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL1078440 | — | EC50 | = | 46773.51 | nM | 4.33 |
| CHEMBL1078818 | — | EC50 | = | 60255.96 | nM | 4.22 |
| CHEMBL1077883 | — | EC50 | = | 69183.1 | nM | 4.16 |
| CHEMBL1078920 | — | EC50 | = | 77624.71 | nM | 4.11 |
| CHEMBL1077983 | — | EC50 | = | 77624.71 | nM | 4.11 |
| CHEMBL1077874 | — | EC50 | = | 123026.88 | nM | - |
| CHEMBL1077873 | — | EC50 | = | 141253.75 | nM | - |
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | EC50 | = | 341979.44 | nM | - |
| CHEMBL6731 | TENAMFETAMINE | EC50 | = | 1905460.72 | nM | - |
| CHEMBL1077962 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL1077961 | — | EC50 | = | 1819700.86 | nM | - |
| CHEMBL1077857 | — | EC50 | = | 398107.17 | nM | - |
| CHEMBL1077884 | — | EC50 | = | 354813.39 | nM | - |
| CHEMBL1078836 | — | EC50 | = | 741310.24 | nM | - |
| CHEMBL1078835 | — | EC50 | = | 489778.82 | nM | - |
| CHEMBL1078510 | — | EC50 | = | 1778279.41 | nM | - |
| CHEMBL1079254 | — | EC50 | = | 190546.07 | nM | - |
| CHEMBL1079149 | — | EC50 | = | 316227.77 | nM | - |
| CHEMBL1079148 | — | EC50 | = | 338844.16 | nM | - |
| CHEMBL1078039 | — | EC50 | = | 1000000.0 | nM | - |
| CHEMBL1078038 | — | EC50 | = | 128824.96 | nM | - |
| CHEMBL1078837 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL1077872 | — | EC50 | = | 131825.67 | nM | - |
| CHEMBL1078351 | — | EC50 | = | 398107.17 | nM | - |
| CHEMBL1078716 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL1079058 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL1078352 | — | EC50 | = | 134896.29 | nM | - |
| CHEMBL1079057 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL1077897 | — | EC50 | = | 281838.29 | nM | - |
| CHEMBL193309 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL1078099 | — | EC50 | > | 10000000.0 | nM | - |
| CHEMBL1078183 | — | EC50 | = | 309029.54 | nM | - |
| CHEMBL1077901 | — | EC50 | = | 1905460.72 | nM | - |
| CHEMBL1077900 | — | EC50 | = | 158489.32 | nM | - |
| CHEMBL1077898 | — | EC50 | = | 257039.58 | nM | - |
| CHEMBL1077899 | — | EC50 | = | 269153.48 | nM | - |