Assay Detail
Functional
CHEMBL1212085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-T. cruzi activities and QSAR studies of 3-arylquinoxaline-2-carbonitrile di-N-oxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 76 | 4.83 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1209414 | — | — | 1 | 5.19 |
| CHEMBL1209415 | — | — | 1 | 5.17 |
| CHEMBL1208868 | — | — | 1 | 5.15 |
| CHEMBL523618 | — | — | 1 | 5.14 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.11 |
| CHEMBL1208870 | — | — | 1 | 5.11 |
| CHEMBL490076 | — | — | 1 | 5.09 |
| CHEMBL490074 | — | — | 1 | 5.08 |
| CHEMBL523962 | — | — | 1 | 5.04 |
| CHEMBL454151 | — | — | 1 | 5.04 |
| CHEMBL1209283 | — | — | 1 | 5.00 |
| CHEMBL1209354 | — | — | 1 | 4.98 |
| CHEMBL1209353 | — | — | 1 | 4.98 |
| CHEMBL490275 | — | — | 1 | 4.97 |
| CHEMBL1209417 | — | — | 1 | 4.97 |
| CHEMBL490075 | — | — | 1 | 4.97 |
| CHEMBL510626 | — | — | 1 | 4.97 |
| CHEMBL1209219 | — | — | 1 | 4.95 |
| CHEMBL472919 | — | — | 1 | 4.95 |
| CHEMBL1209282 | — | — | 1 | 4.92 |
| CHEMBL489880 | — | — | 1 | 4.91 |
| CHEMBL1209891 | — | — | 1 | 4.90 |
| CHEMBL1209889 | — | — | 1 | 4.90 |
| CHEMBL1208867 | — | — | 1 | 4.89 |
| CHEMBL1209351 | — | — | 1 | 4.88 |
| CHEMBL472719 | — | — | 1 | 4.88 |
| CHEMBL1209350 | — | — | 1 | 4.88 |
| CHEMBL521926 | — | — | 1 | 4.88 |
| CHEMBL489291 | — | — | 1 | 4.87 |
| CHEMBL466415 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1209414 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1209415 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL1208868 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL523618 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1208870 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL490076 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL490074 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL523962 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL454151 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1209283 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1209354 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1209353 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL490075 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1209417 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL490275 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL510626 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1209219 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL472919 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1209282 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL489880 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL1209891 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL1209889 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1208867 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL521926 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL472719 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1209351 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL1209350 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL489291 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL466415 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL473520 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL514456 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL1209220 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL514296 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL451313 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL516069 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1209103 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL489882 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL489290 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL490289 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1208869 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1209886 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL447430 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL1209163 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL490288 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL475290 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL506804 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL488362 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL508769 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL451452 | — | IC50 | = | 16400.0 | nM | 4.79 |