Assay Detail
Binding
CHEMBL1219871
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Inhibition of PKD1 assessed as inhibition of HDAC5 neuclear export
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 6.62 | 7.77 |
| IC50 | 1 | 7.50 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215151 | — | — | 1 | 7.77 |
| CHEMBL1215000 | — | — | 1 | 7.62 |
| CHEMBL1214998 | — | — | 1 | 7.50 |
| CHEMBL1215078 | — | — | 1 | 7.18 |
| CHEMBL1214999 | — | — | 1 | 7.11 |
| CHEMBL1215153 | — | — | 1 | 7.04 |
| CHEMBL1215363 | — | — | 1 | 6.94 |
| CHEMBL1215076 | — | — | 1 | 6.70 |
| CHEMBL1215219 | — | — | 1 | 6.63 |
| CHEMBL1215360 | — | — | 1 | 6.47 |
| CHEMBL1215149 | — | — | 1 | 6.42 |
| CHEMBL1215150 | — | — | 1 | 6.37 |
| CHEMBL1215002 | — | — | 1 | 6.36 |
| CHEMBL1215075 | — | — | 1 | 6.32 |
| CHEMBL1215361 | — | — | 1 | 6.25 |
| CHEMBL1215074 | — | — | 1 | 6.17 |
| CHEMBL1215222 | — | — | 1 | 6.17 |
| CHEMBL1215152 | — | — | 1 | 6.15 |
| CHEMBL1215286 | — | — | 1 | 6.12 |
| CHEMBL1215223 | — | — | 1 | 6.08 |
| CHEMBL1215362 | — | — | 1 | - |
| CHEMBL1215288 | — | — | 1 | - |
| CHEMBL1215287 | — | — | 1 | - |
| CHEMBL1215285 | — | — | 1 | - |
| CHEMBL1215221 | — | — | 1 | - |
| CHEMBL1215220 | — | — | 1 | - |
| CHEMBL1215001 | — | — | 1 | - |
| CHEMBL1215077 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215151 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1215000 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1214998 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1215078 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1214999 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1215153 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1215363 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1215076 | — | EC50 | = | 202.0 | nM | 6.70 |
| CHEMBL1215219 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL1215360 | — | EC50 | = | 342.0 | nM | 6.47 |
| CHEMBL1215149 | — | EC50 | = | 378.0 | nM | 6.42 |
| CHEMBL1215150 | — | EC50 | = | 428.0 | nM | 6.37 |
| CHEMBL1215002 | — | EC50 | = | 438.0 | nM | 6.36 |
| CHEMBL1215075 | — | EC50 | = | 478.0 | nM | 6.32 |
| CHEMBL1215361 | — | EC50 | = | 568.0 | nM | 6.25 |
| CHEMBL1215074 | — | EC50 | = | 674.0 | nM | 6.17 |
| CHEMBL1215222 | — | EC50 | = | 679.0 | nM | 6.17 |
| CHEMBL1215152 | — | EC50 | = | 704.0 | nM | 6.15 |
| CHEMBL1215286 | — | EC50 | = | 752.0 | nM | 6.12 |
| CHEMBL1215223 | — | EC50 | = | 831.0 | nM | 6.08 |
| CHEMBL1215362 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215288 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215287 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215285 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215221 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215220 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215001 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL1215077 | — | EC50 | > | 1000.0 | nM | - |