Assay Detail
Functional
CHEMBL1228032
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Antimicrobial activity against Giardia intestinalis IMSS:0696:1 after 48 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and in vitro antiprotozoal, antimycobacterial activities of N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.22 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223560 | — | — | 1 | 8.10 |
| CHEMBL1223557 | — | — | 1 | 6.57 |
| CHEMBL1223559 | — | — | 1 | 6.47 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.40 |
| CHEMBL1222473 | — | — | 1 | 6.22 |
| CHEMBL1223558 | — | — | 1 | 6.03 |
| CHEMBL1223489 | — | — | 1 | 5.93 |
| CHEMBL99254 | — | — | 1 | 5.90 |
| CHEMBL1223488 | — | — | 1 | 5.78 |
| CHEMBL1223561 | — | — | 1 | 5.76 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223560 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1223557 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL1223559 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL1222473 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL1223558 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL1223489 | — | IC50 | = | 1171.0 | nM | 5.93 |
| CHEMBL99254 | — | IC50 | = | 1253.0 | nM | 5.90 |
| CHEMBL1223488 | — | IC50 | = | 1647.0 | nM | 5.78 |
| CHEMBL1223561 | — | IC50 | = | 1748.0 | nM | 5.76 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 5360.0 | nM | 5.27 |