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Compound Detail

CHEMBL1223559

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CCOc1ccc(NC(=O)NCCNc2ccnc3cc(Cl)ccc23)cc1

Basic Information

ChEMBL ID CHEMBL1223559
Phase Preclinical
Structure Type MOL
InChI Key CXNSZXUSERRXPG-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

384.9
MW (Da)
4.52
ALogP
4
HBA
3
HBD
75.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H21ClN4O2
MW 384.87
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -1.86

Activity Summary

IC50 5 meas. best 6.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 6.47 6.47 339.0 1
Entamoeba histolytica
CHEMBL612853
IC50 5.23 5.23 5934.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 4.52 4.52 30128.0 1
Trypanosoma cruzi
CHEMBL368
IC50 4.3 4.3 50000.0 1
Leishmania mexicana
CHEMBL612880
IC50 4.3 4.3 50000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20674375 10.1016/j.bmc.2010.07.008 Giardia intestinalis 1
20674375 10.1016/j.bmc.2010.07.008 Trichomonas vaginalis 1
20674375 10.1016/j.bmc.2010.07.008 Entamoeba histolytica 1
20674375 10.1016/j.bmc.2010.07.008 Leishmania mexicana 1
20674375 10.1016/j.bmc.2010.07.008 Trypanosoma cruzi 1
20674375 10.1016/j.bmc.2010.07.008 Mycobacterium tuberculosis 1

Data from ChEMBL 36 via Core Engine