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Compound Detail

CHEMBL1223558

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O=C(NCCNc1ccnc2cc(Cl)ccc12)Nc1ccc(F)cc1

Basic Information

ChEMBL ID CHEMBL1223558
Phase Preclinical
Structure Type MOL
InChI Key GCWUADMDCHNCOO-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

358.8
MW (Da)
4.26
ALogP
3
HBA
3
HBD
66.0
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H16ClFN4O
MW 358.80
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -2.08

Activity Summary

IC50 3 meas. best 6.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 6.03 6.03 927.0 1
Entamoeba histolytica
CHEMBL612853
IC50 4.75 4.75 17664.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 4.63 4.63 23212.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20674375 10.1016/j.bmc.2010.07.008 Giardia intestinalis 1
20674375 10.1016/j.bmc.2010.07.008 Trichomonas vaginalis 1
20674375 10.1016/j.bmc.2010.07.008 Entamoeba histolytica 1
20674375 10.1016/j.bmc.2010.07.008 Leishmania mexicana 1
20674375 10.1016/j.bmc.2010.07.008 Trypanosoma cruzi 1
20674375 10.1016/j.bmc.2010.07.008 Mycobacterium tuberculosis 1

Data from ChEMBL 36 via Core Engine