Assay Detail
Functional
CHEMBL1284252
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Antiviral activity against Human herpesvirus 6A GS infected in human HSB-2 cells
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human herpesvirus 6A |
| Cell Type | HSB-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.56 | 7.30 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502317 | — | — | 1 | 7.30 |
| CHEMBL223160 | — | — | 1 | 6.00 |
| CHEMBL473586 | — | — | 1 | 5.70 |
| CHEMBL1276696 | — | — | 1 | 5.14 |
| CHEMBL61733 | PMEDAP | — | 1 | 4.82 |
| CHEMBL1276695 | — | — | 1 | 4.42 |
| CHEMBL418216 | — | — | 1 | - |
| CHEMBL1276665 | — | — | 1 | - |
| CHEMBL63849 | — | — | 1 | - |
| CHEMBL1275686 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502317 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL223160 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL473586 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1276696 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL61733 | PMEDAP | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1276695 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL418216 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1276665 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL63849 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1275686 | — | EC50 | > | 50000.0 | nM | - |