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Assay Detail

CHEMBL1286003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Y assessed as viability after 24 hrs by trypan blue exclusion assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.
Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH.
Bioorg Med Chem (2010) 18 : 7826 -7835
PubMed 20961766 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.79 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1275672 1 5.64
CHEMBL1276229 1 5.43
CHEMBL1276302 1 5.35
CHEMBL110 BENZNIDAZOLE 4.0 1 5.30
CHEMBL1276230 1 5.13
CHEMBL1276198 1 5.00
CHEMBL1276228 1 5.00
CHEMBL313679 1 4.96
CHEMBL90512 1 4.40
CHEMBL1276231 1 4.36
CHEMBL1277145 1 4.26
CHEMBL1277144 1 4.11
CHEMBL1276300 1 4.08
CHEMBL1276301 1 4.07
CHEMBL1276255 1 -
CHEMBL1276197 1 -
CHEMBL1277057 1 -
CHEMBL1276253 1 -
CHEMBL1276254 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1275672 IC50 = 2300.0 nM 5.64
CHEMBL1276229 IC50 = 3700.0 nM 5.43
CHEMBL1276302 IC50 = 4500.0 nM 5.35
CHEMBL110 BENZNIDAZOLE IC50 = 5000.0 nM 5.30
CHEMBL1276230 IC50 = 7400.0 nM 5.13
CHEMBL1276198 IC50 = 10000.0 nM 5.00
CHEMBL1276228 IC50 = 10100.0 nM 5.00
CHEMBL313679 IC50 = 11100.0 nM 4.96
CHEMBL90512 IC50 = 39500.0 nM 4.40
CHEMBL1276231 IC50 = 44200.0 nM 4.36
CHEMBL1277145 IC50 = 54600.0 nM 4.26
CHEMBL1277144 IC50 = 76900.0 nM 4.11
CHEMBL1276300 IC50 = 82400.0 nM 4.08
CHEMBL1276301 IC50 = 84800.0 nM 4.07
CHEMBL1276255 IC50 - -
CHEMBL1276197 IC50 = 158000.0 nM -
CHEMBL1277057 IC50 = 148100.0 nM -
CHEMBL1276253 IC50 - -
CHEMBL1276254 IC50 - -