Assay Detail
Functional
CHEMBL1286531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against promastigotes of Leishmania amazonensis WHO/BR/00/LT0016 after 18 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.05 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.31 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 5.53 |
| CHEMBL250270 | LERCANIDIPINE | 3.0 | 1 | 4.77 |
| CHEMBL1275868 | AZELNIDIPINE | 3.0 | 1 | 4.69 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 4.58 |
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 4.42 |
| CHEMBL452076 | CILNIDIPINE | 3.0 | 1 | - |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | - |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | - |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | 3.0 | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL250270 | LERCANIDIPINE | IC50 | = | 16950.0 | nM | 4.77 |
| CHEMBL1275868 | AZELNIDIPINE | IC50 | = | 20540.0 | nM | 4.69 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL475534 | NITRENDIPINE | IC50 | = | 38320.0 | nM | 4.42 |
| CHEMBL452076 | CILNIDIPINE | IC50 | = | 110670.0 | nM | - |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 117890.0 | nM | - |
| CHEMBL1428 | NIMODIPINE | IC50 | = | 128160.0 | nM | - |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | IC50 | - | — | - | |
| CHEMBL110 | BENZNIDAZOLE | IC50 | - | — | - |