Compound Detail
CHEMBL250270
LERCANIDIPINE 🧪 Phase III
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🧪 Phase III
COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1
Basic Information
| ChEMBL ID | CHEMBL250270 |
| Name | LERCANIDIPINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | ZDXUKAKRHYTAKV-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
6
Targets
9
Activities
1
Assay Types
1
PK Parameters
20
Publications
3
Known Names
3
Indications
Molecular Properties
611.7
MW (Da)
6.48
ALogP
8
HBA
1
HBD
111.0
PSA (Ų)
0.14
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Cardiovascular Diseases Hypertension Essential Hypertension
ATC Classification
C08CA13
lercanidipine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: CALCIUM CHANNEL BLOCKERS
Activity Summary
IC50 9 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.66 | 5.225 | 2200.0 | 2 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 5.07 | 5.07 | 8430.0 | 1 |
| Leishmania chagasi CHEMBL612790 | IC50 | 4.99 | 4.855 | 10360.0 | 2 |
| Leishmania braziliensis CHEMBL612878 | IC50 | 4.99 | 4.99 | 10330.0 | 1 |
| Leishmania major CHEMBL612879 | IC50 | 4.94 | 4.94 | 11550.0 | 1 |
| Leishmania amazonensis CHEMBL612877 | IC50 | 4.77 | 4.77 | 16950.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 124.6 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine