Assay Detail
Functional
CHEMBL1286533
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Antileishmanial activity against promastigotes of Leishmania braziliensis MHO/BR/75/M2903 after 18 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania braziliensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.95 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 6.82 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 5.50 |
| CHEMBL250270 | LERCANIDIPINE | 3.0 | 1 | 4.99 |
| CHEMBL1275868 | AZELNIDIPINE | 3.0 | 1 | 4.86 |
| CHEMBL452076 | CILNIDIPINE | 3.0 | 1 | 4.82 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 4.72 |
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 4.41 |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 4.37 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 4.02 |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | 3.0 | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL250270 | LERCANIDIPINE | IC50 | = | 10330.0 | nM | 4.99 |
| CHEMBL1275868 | AZELNIDIPINE | IC50 | = | 13670.0 | nM | 4.86 |
| CHEMBL452076 | CILNIDIPINE | IC50 | = | 15260.0 | nM | 4.82 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 19080.0 | nM | 4.72 |
| CHEMBL475534 | NITRENDIPINE | IC50 | = | 39040.0 | nM | 4.41 |
| CHEMBL1428 | NIMODIPINE | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 95740.0 | nM | 4.02 |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | IC50 | - | — | - | |
| CHEMBL110 | BENZNIDAZOLE | IC50 | - | — | - |