Compound Detail
CHEMBL1275868
AZELNIDIPINE 🧪 Phase III
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
🧪 Phase III
CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1
Basic Information
| ChEMBL ID | CHEMBL1275868 |
| Name | AZELNIDIPINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | ZKFQEACEUNWPMT-UHFFFAOYSA-N |
7
Targets
10
Activities
1
Assay Types
1
PK Parameters
20
Publications
5
Known Names
1
Mechanisms
Molecular Properties
582.7
MW (Da)
4.69
ALogP
9
HBA
2
HBD
137.0
PSA (Ų)
0.21
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Voltage-gated L-type calcium channel blocker | BLOCKER | Voltage-gated L-type calcium channel | ✓ | ✓ |
Activity Summary
IC50 10 meas. best 5.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.91 | 5.345 | 1234.0 | 4 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
| Leishmania braziliensis CHEMBL612878 | IC50 | 4.86 | 4.86 | 13670.0 | 1 |
| Leishmania major CHEMBL612879 | IC50 | 4.77 | 4.77 | 17060.0 | 1 |
| Leishmania amazonensis CHEMBL612877 | IC50 | 4.69 | 4.69 | 20540.0 | 1 |
| Leishmania chagasi CHEMBL612790 | IC50 | 4.48 | 4.48 | 33390.0 | 1 |
| LLC-MK2 CHEMBL614691 | IC50 | 4.47 | 4.47 | 33480.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 33.9 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine