Assay Detail
Functional
CHEMBL1286529
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Antileishmanial activity against promastigotes of Leishmania chagasi MHOM/BR/1972/LD after 18 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania chagasi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.74 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.96 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 5.58 |
| CHEMBL250270 | LERCANIDIPINE | 3.0 | 1 | 4.72 |
| CHEMBL1275868 | AZELNIDIPINE | 3.0 | 1 | 4.48 |
| CHEMBL452076 | CILNIDIPINE | 3.0 | 1 | 4.48 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 4.45 |
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 4.19 |
| CHEMBL1428 | NIMODIPINE | 4.0 | 1 | 4.08 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | - |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | 3.0 | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL1491 | AMLODIPINE | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL250270 | LERCANIDIPINE | IC50 | = | 19170.0 | nM | 4.72 |
| CHEMBL1275868 | AZELNIDIPINE | IC50 | = | 33390.0 | nM | 4.48 |
| CHEMBL452076 | CILNIDIPINE | IC50 | = | 33010.0 | nM | 4.48 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 35660.0 | nM | 4.45 |
| CHEMBL475534 | NITRENDIPINE | IC50 | = | 64130.0 | nM | 4.19 |
| CHEMBL1428 | NIMODIPINE | IC50 | = | 82680.0 | nM | 4.08 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 146410.0 | nM | - |
| CHEMBL239129 | MEGLUMINE ANTIMONATE | IC50 | - | — | - | |
| CHEMBL110 | BENZNIDAZOLE | IC50 | - | — | - |