Assay Detail
Functional
CHEMBL1291264
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Cytotoxicity against human DU145 after 48 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.69 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404613 | DEOXYBOUVARDIN | — | 1 | 8.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.00 |
| CHEMBL1288988 | — | — | 1 | 6.23 |
| CHEMBL1288982 | RUBIYUNNANIN C | — | 1 | 6.17 |
| CHEMBL1288989 | — | — | 1 | 5.69 |
| CHEMBL1288990 | — | — | 1 | 5.54 |
| CHEMBL1288991 | — | — | 1 | 4.97 |
| CHEMBL1288983 | RUBIYUNNANIN D | — | 1 | 4.80 |
| CHEMBL1288986 | RUBIYUNNANIN G | — | 1 | 4.44 |
| CHEMBL1288985 | RUBIYUNNANIN F | — | 1 | 4.38 |
| CHEMBL1288984 | RUBIYUNNANIN E | — | 1 | 4.36 |
| CHEMBL1288987 | RUBIYUNNANIN H | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404613 | DEOXYBOUVARDIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1288988 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1288982 | RUBIYUNNANIN C | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1288989 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL1288990 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL1288991 | — | IC50 | = | 10650.0 | nM | 4.97 |
| CHEMBL1288983 | RUBIYUNNANIN D | IC50 | = | 15830.0 | nM | 4.80 |
| CHEMBL1288986 | RUBIYUNNANIN G | IC50 | = | 36290.0 | nM | 4.44 |
| CHEMBL1288985 | RUBIYUNNANIN F | IC50 | = | 41620.0 | nM | 4.38 |
| CHEMBL1288984 | RUBIYUNNANIN E | IC50 | = | 43730.0 | nM | 4.36 |
| CHEMBL1288987 | RUBIYUNNANIN H | IC50 | > | 50000.0 | nM | - |