Assay Detail
Binding
CHEMBL1613786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Confirmation of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1434, AID1438, AID1496, AID1550, AID1645]
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Category | confirmatory |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Runt-related transcription factor 1/Core-binding factor subunit beta (CHEMBL2093862) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.24 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1372231 | — | — | 1 | 6.15 |
| CHEMBL1323994 | — | — | 1 | 5.73 |
| CHEMBL1483506 | — | — | 1 | 5.45 |
| CHEMBL1353698 | — | — | 1 | 5.44 |
| CHEMBL1380684 | — | — | 1 | 5.07 |
| CHEMBL1490677 | — | — | 1 | 4.99 |
| CHEMBL1453190 | — | — | 1 | 4.89 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | 4.0 | 1 | 4.87 |
| CHEMBL1519408 | — | — | 1 | 4.57 |
| CHEMBL1364045 | — | — | 1 | - |
| CHEMBL1419943 | — | — | 1 | - |
| CHEMBL1330155 | — | — | 1 | - |
| CHEMBL1450979 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1372231 | — | IC50 | = | 713.43 | nM | 6.15 |
| CHEMBL1323994 | — | IC50 | = | 1865.2 | nM | 5.73 |
| CHEMBL1483506 | — | IC50 | = | 3575.7 | nM | 5.45 |
| CHEMBL1353698 | — | IC50 | = | 3636.5 | nM | 5.44 |
| CHEMBL1380684 | — | IC50 | = | 8480.0 | nM | 5.07 |
| CHEMBL1490677 | — | IC50 | = | 10337.0 | nM | 4.99 |
| CHEMBL1453190 | — | IC50 | = | 12809.0 | nM | 4.89 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | IC50 | = | 13417.0 | nM | 4.87 |
| CHEMBL1519408 | — | IC50 | = | 26648.0 | nM | 4.57 |
| CHEMBL1364045 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1419943 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1330155 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1450979 | — | IC50 | > | 100000.0 | nM | - |