Assay Detail

CHEMBL1660144

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Functional

Antitrypanosomal activity against Trypanosoma cruzi 960 epimastigotes after 24 hrs by light microscopy

ChEMBL ↗

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Target

Trypanosoma cruzi (CHEMBL368) ↗

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Trypanosoma cruzi (CHEMBL368) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma cruzi

CHEMBL368

Anchored from Assay target.

Protein identity Trypanosoma cruzi

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma cruzi
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗

Type	ORGANISM
Organism	Trypanosoma cruzi

Publication

Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment.

Batista Dda G, Batista MM, de Oliveira GM, do Amaral PB, Lannes-Vieira J, Britto CC, Junqueira A, Lima MM, Romanha AJ, Sales Junior PA, Stephens CE, Boykin DW, Soeiro Mde N.
Antimicrob Agents Chemother (2010) 54 : 2940 -2952
PubMed 20457822 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.12	7.05
IC90	2	-	-

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1275764	—	—	2	7.05
CHEMBL110	BENZNIDAZOLE	4.0	2	5.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1275764	—	IC50	=	90.0	nM	7.05
CHEMBL110	BENZNIDAZOLE	IC50	=	6440.0	nM	5.19
CHEMBL110	BENZNIDAZOLE	IC90	=	38170.0	nM	-
CHEMBL1275764	—	IC90	=	280.0	nM	-