Assay Detail
Functional
CHEMBL1670350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Type-1 angiotensin II receptor (CHEMBL3948) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.55 | 9.20 |
| IC50 | 2 | 8.48 | 10.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48242 | — | — | 1 | 10.26 |
| CHEMBL433895 | — | — | 1 | 9.20 |
| CHEMBL123713 | — | — | 1 | 7.90 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | 4.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48242 | — | IC50 | = | 0.055 | nM | 10.26 |
| CHEMBL433895 | — | Kd | = | 0.631 | nM | 9.20 |
| CHEMBL123713 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL1014 | CANDESARTAN CILEXETIL | IC50 | = | 200.0 | nM | 6.70 |