Assay Detail
Functional
CHEMBL1685249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 9.54 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682213 | — | — | 1 | 10.30 |
| CHEMBL1682210 | — | — | 1 | 10.15 |
| CHEMBL1682212 | — | — | 1 | 10.05 |
| CHEMBL1682214 | — | — | 1 | 9.89 |
| CHEMBL1682211 | — | — | 1 | 9.70 |
| CHEMBL1682215 | — | — | 1 | 9.70 |
| CHEMBL1682216 | — | — | 1 | 9.70 |
| CHEMBL1682217 | — | — | 1 | 9.70 |
| CHEMBL1682218 | — | — | 1 | 9.70 |
| CHEMBL1682219 | — | — | 1 | 9.15 |
| CHEMBL1682302 | — | — | 1 | 9.05 |
| CHEMBL1682221 | — | — | 1 | 9.00 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | 9.00 |
| CHEMBL1682220 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682213 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1682210 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL1682212 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL1682214 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL1682211 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1682215 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1682216 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1682217 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1682218 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1682219 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1682302 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1682221 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1346 | DARIFENACIN | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1682220 | — | EC50 | = | 3.2 | nM | 8.49 |