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Compound Detail

CHEMBL1682218

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O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL1682218
Phase Preclinical
Structure Type MOL
InChI Key RHAYOMZUUNTCTB-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

548.6
MW (Da)
5.01
ALogP
5
HBA
6
HBD
126.5
PSA (Ų)
0.14
QED
3
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H32N4O4
MW 548.64
Aromatic Rings 5
Heavy Atoms 41
NP-Likeness -0.53

Activity Summary

EC50 2 meas. best 9.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL5414
EC50 9.7 9.7 0.2 1
Beta-1 adrenergic receptor
CHEMBL3252
EC50 5.05 5.05 8890.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21277205 10.1016/j.bmcl.2010.12.096 Cavia porcellus 2
21277205 10.1016/j.bmcl.2010.12.096 NON-PROTEIN TARGET 1
21277205 10.1016/j.bmcl.2010.12.096 Beta-2 adrenergic receptor 1
21277205 10.1016/j.bmcl.2010.12.096 Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine