Assay Detail
Functional
CHEMBL1685250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at beta1 adrenoceptor in rat left atria assessed as induction of ionotropic effect
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.64 | 6.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1682220 | — | — | 1 | 6.53 |
| CHEMBL1682215 | — | — | 1 | 6.26 |
| CHEMBL1682211 | — | — | 1 | 6.05 |
| CHEMBL1682217 | — | — | 1 | 5.80 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | 5.64 |
| CHEMBL1682219 | — | — | 1 | 5.24 |
| CHEMBL1682216 | — | — | 1 | 5.20 |
| CHEMBL1682218 | — | — | 1 | 5.05 |
| CHEMBL1682221 | — | — | 1 | 5.00 |
| CHEMBL1682210 | — | — | 1 | - |
| CHEMBL1682212 | — | — | 1 | - |
| CHEMBL1682213 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1682220 | — | EC50 | = | 296.0 | nM | 6.53 |
| CHEMBL1682215 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1682211 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1682217 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1346 | DARIFENACIN | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL1682219 | — | EC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL1682216 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1682218 | — | EC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL1682221 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1682210 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1682212 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1682213 | — | EC50 | > | 10000.0 | nM | - |