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Compound Detail

CHEMBL1682215

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COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1

Basic Information

ChEMBL ID CHEMBL1682215
Phase Preclinical
Structure Type MOL
InChI Key XPPGERQSEMHJHQ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

502.6
MW (Da)
3.43
ALogP
6
HBA
6
HBD
135.7
PSA (Ų)
0.18
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H30N4O5
MW 502.57
Aromatic Rings 4
Heavy Atoms 37
NP-Likeness -0.60

Activity Summary

EC50 2 meas. best 9.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL5414
EC50 9.7 9.7 0.2 1
Beta-1 adrenergic receptor
CHEMBL3252
EC50 6.26 6.26 550.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21277205 10.1016/j.bmcl.2010.12.096 NON-PROTEIN TARGET 1
21277205 10.1016/j.bmcl.2010.12.096 Beta-2 adrenergic receptor 1
21277205 10.1016/j.bmcl.2010.12.096 Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine