Assay Detail
Binding
CHEMBL1686566
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Inhibition of rat intestinal sucrase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.84 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476960 | VOGLIBOSE | 4.0 | 1 | 6.70 |
| CHEMBL1258528 | PONKORANOL | — | 1 | 6.54 |
| CHEMBL1684166 | — | — | 1 | 6.52 |
| CHEMBL1093264 | KOTALANOL | — | 1 | 6.12 |
| CHEMBL1258529 | NEOPONKORANOL | — | 1 | 6.00 |
| CHEMBL1684162 | NEOSALACINOL | — | 1 | 5.89 |
| CHEMBL1208974 | SALACINOL | — | 1 | 5.80 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | 5.77 |
| CHEMBL1258643 | — | — | 1 | 5.54 |
| CHEMBL1232371 | NEOKOTALANOL | — | 1 | 5.35 |
| CHEMBL1684163 | NEOSALAPRINOL | — | 1 | 4.05 |
| CHEMBL1209027 | SALAPRINOL | — | 1 | - |
| CHEMBL1684164 | — | — | 1 | - |
| CHEMBL1684165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476960 | VOGLIBOSE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1258528 | PONKORANOL | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1684166 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1093264 | KOTALANOL | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1258529 | NEOPONKORANOL | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1684162 | NEOSALACINOL | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1208974 | SALACINOL | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1258643 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1232371 | NEOKOTALANOL | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1684163 | NEOSALAPRINOL | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1209027 | SALAPRINOL | IC50 | > | 329000.0 | nM | - |
| CHEMBL1684164 | — | IC50 | > | 329000.0 | nM | - |
| CHEMBL1684165 | — | IC50 | > | 384000.0 | nM | - |