Assay Detail
Functional
CHEMBL1687173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.03 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.95 |
| CHEMBL1682911 | — | — | 1 | 5.69 |
| CHEMBL1682910 | — | — | 1 | 5.64 |
| CHEMBL1682931 | — | — | 1 | 5.30 |
| CHEMBL1682909 | — | — | 1 | 5.27 |
| CHEMBL1682912 | — | — | 1 | 5.27 |
| CHEMBL1682907 | — | — | 1 | 5.20 |
| CHEMBL1682914 | — | — | 1 | 5.18 |
| CHEMBL1681800 | — | — | 1 | 5.10 |
| CHEMBL1682928 | — | — | 1 | 5.05 |
| CHEMBL1682933 | — | — | 1 | 5.03 |
| CHEMBL1651330 | STELLARINES A | — | 1 | 4.84 |
| CHEMBL1682913 | — | — | 1 | 4.79 |
| CHEMBL1682926 | — | — | 1 | 4.78 |
| CHEMBL1682906 | — | — | 1 | 4.75 |
| CHEMBL1682915 | — | — | 1 | 4.75 |
| CHEMBL1682930 | — | — | 1 | 4.52 |
| CHEMBL1682932 | — | — | 1 | 4.52 |
| CHEMBL1682927 | — | — | 1 | 4.52 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.42 |
| CHEMBL1682924 | — | — | 1 | - |
| CHEMBL1682925 | — | — | 1 | - |
| CHEMBL1682923 | — | — | 1 | - |
| CHEMBL1682922 | — | — | 1 | - |
| CHEMBL1682921 | — | — | 1 | - |
| CHEMBL1682920 | — | — | 1 | - |
| CHEMBL1682919 | — | — | 1 | - |
| CHEMBL1682918 | — | — | 1 | - |
| CHEMBL1682917 | — | — | 1 | - |
| CHEMBL1682916 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL1682911 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL1682910 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL1682931 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL1682909 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL1682912 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL1682907 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL1682914 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL1681800 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL1682928 | — | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL1682933 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1651330 | STELLARINES A | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL1682913 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1682926 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL1682906 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1682915 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL1682930 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1682932 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1682927 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL1682924 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682925 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682923 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682922 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682921 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682920 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682919 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682918 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682917 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682916 | — | IC50 | > | 30000.0 | nM | - |