Assay Detail
Functional
CHEMBL1687174
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Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Neutrophil |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.18 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.72 |
| CHEMBL1682910 | — | — | 1 | 5.70 |
| CHEMBL1682911 | — | — | 1 | 5.56 |
| CHEMBL1682912 | — | — | 1 | 5.51 |
| CHEMBL1682907 | — | — | 1 | 5.50 |
| CHEMBL1651330 | STELLARINES A | — | 1 | 5.24 |
| CHEMBL1682914 | — | — | 1 | 5.21 |
| CHEMBL1682913 | — | — | 1 | 4.98 |
| CHEMBL1682915 | — | — | 1 | 4.88 |
| CHEMBL1682906 | — | — | 1 | 4.87 |
| CHEMBL1682928 | — | — | 1 | 4.85 |
| CHEMBL1682909 | — | — | 1 | 4.83 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.50 |
| CHEMBL1682916 | — | — | 1 | - |
| CHEMBL1682917 | — | — | 1 | - |
| CHEMBL1682918 | — | — | 1 | - |
| CHEMBL1682919 | — | — | 1 | - |
| CHEMBL1682920 | — | — | 1 | - |
| CHEMBL1682921 | — | — | 1 | - |
| CHEMBL1682922 | — | — | 1 | - |
| CHEMBL1682923 | — | — | 1 | - |
| CHEMBL1682925 | — | — | 1 | - |
| CHEMBL1681800 | — | — | 1 | - |
| CHEMBL1682927 | — | — | 1 | - |
| CHEMBL1682930 | — | — | 1 | - |
| CHEMBL1682931 | — | — | 1 | - |
| CHEMBL1682933 | — | — | 1 | - |
| CHEMBL1682932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98350 | LY-294002 | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL1682910 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL1682911 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL1682912 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL1682907 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL1651330 | STELLARINES A | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL1682914 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL1682913 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1682915 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL1682906 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL1682928 | — | IC50 | = | 14170.0 | nM | 4.85 |
| CHEMBL1682909 | — | IC50 | = | 14830.0 | nM | 4.83 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1682916 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682917 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682918 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682919 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682920 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682921 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682922 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682923 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682925 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1681800 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682927 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682930 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682931 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682933 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1682932 | — | IC50 | > | 30000.0 | nM | - |