Assay Detail
Functional
CHEMBL1693144
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Cytotoxicity against human IGROV1 cells after 72 hrs by alamar blue assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.24 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1688857 | — | — | 1 | 7.70 |
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 7.52 |
| CHEMBL1688855 | — | — | 1 | 6.92 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1688857 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1688855 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 160.0 | nM | 6.80 |