Assay Detail
Functional
CHEMBL1776110
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Antiviral activity against Vaccinia virus Copenhagen infected in human HFF cells assessed as reduction in viral-induced cytopathic effect by neutral red uptake assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Broad-spectrum antiviral activity including human immunodeficiency and hepatitis C viruses mediated by a novel retinoid thiosemicarbazone derivative.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.66 | 5.01 |
| EC90 | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 2 | 5.01 |
| CHEMBL241902 | — | — | 2 | 4.84 |
| CHEMBL1774257 | — | — | 2 | 4.13 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 2 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 2 | - |
| CHEMBL1774258 | — | — | 2 | - |
| CHEMBL1774255 | — | — | 2 | - |
| CHEMBL1773084 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL241902 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1774257 | — | EC50 | = | 73600.0 | nM | 4.13 |
| CHEMBL184 | ACYCLOVIR | EC50 | - | — | - | |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL184 | ACYCLOVIR | EC90 | - | — | - | |
| CHEMBL182 | GANCICLOVIR | EC90 | - | — | - | |
| CHEMBL1774258 | — | EC50 | > | 2400.0 | nM | - |
| CHEMBL1774255 | — | EC90 | > | 300.0 | uM | - |
| CHEMBL1774258 | — | EC90 | > | 2.4 | uM | - |
| CHEMBL1773084 | — | EC50 | = | 110000.0 | nM | - |
| CHEMBL1774255 | — | EC50 | = | 250000.0 | nM | - |
| CHEMBL241902 | — | EC90 | = | 34.5 | uM | - |
| CHEMBL1773084 | — | EC90 | = | 239.0 | uM | - |
| CHEMBL1774257 | — | EC90 | = | 84.9 | uM | - |
| CHEMBL5314375 | CIDOFOVIR | EC90 | = | 20.0 | uM | - |