Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1776697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type HSC-T6
Confidence 1 — Organism
Curated By Autocuration

Publication

Antifibrotic constituents of Alnus firma on hepatic stellate cells.
Lee M, Lee MK, Kim YC, Sung SH.
Bioorg Med Chem Lett (2011) 21 : 2906 -2910
PubMed 21504848 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.52 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297453 EPIGALOCATECHIN GALLATE 3.0 1 5.00
CHEMBL464274 DEHYDROHIRSUTANONOL 1 4.85
CHEMBL1774776 1 4.62
CHEMBL330645 PLATYPHYLLENONE 1 4.46
CHEMBL1774771 1 4.46
CHEMBL1774773 1 4.41
CHEMBL464362 1 4.33
CHEMBL1087992 PLATYPHYLLONE 1 4.26
CHEMBL1774774 1 4.26
CHEMBL1774721 1 -
CHEMBL598970 ALNUSIDE B 1 -
CHEMBL1774772 1 -
CHEMBL464570 OREGONIN 1 -
CHEMBL1774775 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297453 EPIGALOCATECHIN GALLATE IC50 = 9900.0 nM 5.00
CHEMBL464274 DEHYDROHIRSUTANONOL IC50 = 14000.0 nM 4.85
CHEMBL1774776 IC50 = 23900.0 nM 4.62
CHEMBL330645 PLATYPHYLLENONE IC50 = 34700.0 nM 4.46
CHEMBL1774771 IC50 = 34900.0 nM 4.46
CHEMBL1774773 IC50 = 39100.0 nM 4.41
CHEMBL464362 IC50 = 46200.0 nM 4.33
CHEMBL1087992 PLATYPHYLLONE IC50 = 54900.0 nM 4.26
CHEMBL1774774 IC50 = 54900.0 nM 4.26
CHEMBL1774721 IC50 > 100000.0 nM -
CHEMBL598970 ALNUSIDE B IC50 > 100000.0 nM -
CHEMBL1774772 IC50 > 100000.0 nM -
CHEMBL464570 OREGONIN IC50 > 100000.0 nM -
CHEMBL1774775 IC50 > 100000.0 nM -