Assay Detail
Functional
CHEMBL1777323
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Antitrypanosomal activity against epimastigote form of Trypanosoma cruzi assessed as inhibition of parasite growth
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo trypanocidal activity of flavonoids from Delphinium staphisagria against Chagas disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.87 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774168 | ASTRAGALIN HEPTAACETATE | — | 1 | 6.10 |
| CHEMBL1774167 | — | — | 1 | 5.19 |
| CHEMBL233930 | ASTRAGALIN | — | 1 | 4.80 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.80 |
| CHEMBL1774170 | PAEONOSIDE DECAACETATE | — | 1 | 4.76 |
| CHEMBL1079882 | PAEONOSIDE | — | 1 | 4.69 |
| CHEMBL1774169 | — | — | 1 | 4.66 |
| CHEMBL1774173 | PETIOLAROSIDE DECAACETATE | — | 1 | 4.57 |
| CHEMBL1774172 | — | — | 1 | 4.56 |
| CHEMBL1774171 | PETIOLAROSIDE | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774168 | ASTRAGALIN HEPTAACETATE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1774167 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL233930 | ASTRAGALIN | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1774170 | PAEONOSIDE DECAACETATE | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL1079882 | PAEONOSIDE | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL1774169 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL1774173 | PETIOLAROSIDE DECAACETATE | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1774172 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL1774171 | PETIOLAROSIDE | IC50 | = | 30300.0 | nM | 4.52 |