Assay Detail
Functional
CHEMBL1781694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi MHOM/MX/1994/Ninoa epimastigotes after 72 hrs by neubauer chamber
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.82 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1779947 | — | — | 1 | 5.31 |
| CHEMBL1545 | TIZOXANIDE | -1.0 | 1 | 4.76 |
| CHEMBL1401 | NITAZOXANIDE | 4.0 | 1 | 4.73 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 4.46 |
| CHEMBL1779948 | — | — | 1 | - |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1779947 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL1545 | TIZOXANIDE | IC50 | = | 17470.0 | nM | 4.76 |
| CHEMBL1401 | NITAZOXANIDE | IC50 | = | 18730.0 | nM | 4.73 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 34380.0 | nM | 4.46 |
| CHEMBL1779948 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL137 | METRONIDAZOLE | IC50 | > | 50000.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | IC50 | > | 50000.0 | nM | - |