Assay Detail
ADMET
CHEMBL1785124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at alpha3beta4* nAChR in mouse interpeduncular nucleus assessed as [3H]ACh release by scintillation counting relative to control
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Tissue | Interpeduncular nucleus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (CHEMBL3885609) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.07 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217150 | — | — | 1 | 6.40 |
| CHEMBL1783886 | — | — | 1 | 5.62 |
| CHEMBL1783881 | — | — | 1 | 5.48 |
| CHEMBL1782074 | — | — | 1 | 5.25 |
| CHEMBL1783880 | — | — | 1 | 5.02 |
| CHEMBL1783883 | — | — | 1 | 4.80 |
| CHEMBL3215819 | — | — | 1 | 4.68 |
| CHEMBL1783882 | — | — | 1 | 4.55 |
| CHEMBL1783878 | — | — | 1 | 4.47 |
| CHEMBL1783888 | — | — | 1 | 4.39 |
| CHEMBL1783879 | — | — | 1 | - |
| CHEMBL1783884 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217150 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1783886 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1783881 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1782074 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1783880 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1783883 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3215819 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1783882 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1783878 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1783888 | — | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1783879 | — | EC50 | = | 218000.0 | nM | - |
| CHEMBL1783884 | — | EC50 | = | 161000.0 | nM | - |